{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

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Chemical Name:{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine
CAS No.:474103-34-9
Molecular Formula:C₃₂H₃₄Cl₃N₃OSi
Molecular Weight:611.086
Hs Code.:

{5-[1-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

Synonyms:{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

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Chemical Property of {5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

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Technology Process of {5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

There total 6 articles about {5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 474103-33-8
5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-4,6-dichloro-2-methyl-pyrimidine

: 554-00-7,51908-09-9
2,4-Dichloroaniline

: 474103-34-9
{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

Guidance literature:: 2,4-Dichloroaniline; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-4,6-dichloro-2-methyl-pyrimidine; In tetrahydrofuran; for 5h; Heating;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: (4,6-dihydroxy-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester

: 474103-34-9
{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / POCl₃ / 3.5 h / Heating

2.1: 68 percent / LiHMDS / hexane; tetrahydrofuran / 0 - 20 °C

3.1: 86 percent / DIBAl-H / hexane; CH₂Cl₂ / 3 h / -78 - 0 °C

4.1: 90 percent / imidazole; DMAP / dimethylformamide / 2 h / 0 - 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

5.2: 46 percent / tetrahydrofuran / 5 h / Heating

With 1H-imidazole; dmap; sodium hydride; diisobutylaluminium hydride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: 474103-23-6
2-(4,6-dichloro-2-methyl-pyrimidin-5-yl)-pent-4-en-1-ol

: 474103-34-9
{5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / imidazole; DMAP / dimethylformamide / 2 h / 0 - 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 46 percent / tetrahydrofuran / 5 h / Heating

With 1H-imidazole; dmap; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040