Technology Process of Cyclopenta[c][1]benzopyran-3,3a(4H)-diol,1,2,3,5a,8,9,9a,9b-octahydro-7,9a,9b-trimethyl-, (3R,3aS,5aS,9aR,9bR)-
There total 2 articles about Cyclopenta[c][1]benzopyran-3,3a(4H)-diol,1,2,3,5a,8,9,9a,9b-octahydro-7,9a,9b-trimethyl-, (3R,3aS,5aS,9aR,9bR)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 21 percent Turnov. / powdered KOH / 2-methyl-propan-2-ol / 3 h / 83 °C
2: 89 percent / DABCO / various solvent(s) / 36 h / 150 °C
3: 50 percent / Na2HPO4, MCPBA / CH2Cl2 / 1 h / 25 °C
With
1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00222a036
- Guidance literature:
-
With
dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
Yield given. Multistep reaction;
1) CH2Cl2, -78 deg C, 30 min, 2) warm up to -25 deg C in 40 min, then room temperature;
DOI:10.1016/0031-9422(92)80114-T
