4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

Base Information

Chemical Name:4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide
CAS No.:1438389-69-5
Molecular Formula:C₂₁H₃₆N₂O₄SSi
Molecular Weight:440.679
Hs Code.:

Synonyms:4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

Chemical Property:

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Technology Process of 4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

There total 2 articles about 4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1438389-71-9
1-benzyloxycarbonyl-4-(R)-tert-butyldimethylsilyloxy-N-(p-butylbenzenesulfonyl)-2-(S)-pyrrolidinecarboxamide

: 1438389-69-5
4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.tetasy.2013.03.016

Reference yield:

: 104197-68-4
(2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid

: 1438389-69-5
4-tert-(R)-butyldimethylsilyloxy-N'-(p-butylbenzenesulfonyl)-(S)-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h / 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2013.03.016