5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol

Base Information

• Chemical Name: 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol
• CAS No.: 502423-52-1
• Molecular Formula: C₂₃H₃₁NO₃
• Molecular Weight: 369.504

Synonyms:5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol

Chemical Property of 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol

Chemical Property:

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Technology Process of 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol

There total 4 articles about 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butyl-3-[4-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-methoxy-phenyl]-isoxazole → 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol (502423-52-1)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02162-7

Reference yield:

S-ethyl thiopivalate (22872-50-0) → 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol (502423-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / -78 °C

1.2: TsOH / toluene

2.1: EtSNa / dimethylformamide

With n-butyllithium; sodium thioethylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02162-7

Reference yield:

5-(4-acetyl-3-methoxyphenyl)-4-t-butyl-3,3-dimethyl-2,3-dihydrofuran (244124-56-9) → 5-(3-tert-butyl-4,4-dimethyl-4,5-dihydro-furan-2-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol (502423-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NH₂OH / ethanol

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: TsOH / toluene

3.1: EtSNa / dimethylformamide

With n-butyllithium; hydroxylamine; sodium thioethylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02162-7

upstream raw materials:

S-ethyl thiopivalate

5-(4-acetyl-3-methoxyphenyl)-4-t-butyl-3,3-dimethyl-2,3-dihydrofuran

Downstream raw materials:

5-(5-tert-butyl-4,4-dimethyl-2,6,7-trioxa-bicyclo[3.2.0]hept-1-yl)-2-(5-tert-butyl-isoxazol-3-yl)-phenol

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