tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate
CAS No.:1082950-48-8
Molecular Formula:C₂₀H₂₃F₄N₃O₂
Molecular Weight:413.415
Hs Code.:

Synonyms:tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Suppliers and Price of tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.86%

: 1082949-99-2
4-[2-oxo-2-(4-fluoro-3-trifluoromethylphenyl)ethylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

: 1082950-48-8
tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: With ammonium acetate; triethylamine; In butan-1-ol; at 160 ℃; for 3h; Product distribution / selectivity; Sealed tube;

Reference yield:

: 765917-04-2
(4-fluoro-3-trifluoromethylphenyl)-oxoacetaldehyde

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1082950-48-8
tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: With ammonium hydroxide; In methanol; water; at 30 ℃;
DOI:10.1016/j.bmcl.2018.03.092

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: 1082950-48-8
tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / tetrahydrofuran; water / 10 h / -2 - 2 °C / Large scale reaction

2.1: triphenylphosphine / tetrahydrofuran / 26 h / 20 °C / Inert atmosphere; Cooling; Large scale reaction

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,1'-carbonyldiimidazole / tetrahydrofuran; ethyl acetate / 20 - 25 °C / Inert atmosphere; Large scale reaction

3.2: 16.5 h / 20 - 25 °C

4.1: ammonium acetate / methanol / 72 h / 140 °C / Large scale reaction

With sodium azide; ammonium acetate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triphenylphosphine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/op200351g