(E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene

Base Information

• Chemical Name: (E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene
• CAS No.: 227084-60-8
• Molecular Formula: C₂₆H₂₄ClIN₂O₃
• Molecular Weight: 574.846
• Mol file: 227084-60-8.mol

Synonyms:(E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene

Chemical Property of (E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene

There total 1 articles about (E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

E/Z-1,3-Dichloropropene (542-75-6) + N-tert-butoxycarbonyl-4-benzyloxy-7-cyano-1-iodo-2-naphthylamine (178877-17-3) → (E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene (227084-60-8)

Guidance literature:

N-tert-butoxycarbonyl-4-benzyloxy-7-cyano-1-iodo-2-naphthylamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;

E/Z-1,3-Dichloropropene; In N,N-dimethyl-formamide; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1002/ejoc.201000966

Reference yield: 85.0%

(E/Z)-2-amino-4-benzyloxy-N-tert-butoxycarbonyl-N-(3-chloroprop-2-enyl)-7-cyano-1-iodonaphthalene (227084-60-8) → rac-5-benzyloxy-3-tert-butoxycarbonyl-1-chloromethyl-8-cyano-1,2-dihydro-3H-benz[e]indole (178877-13-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In toluene; at 2 - 80 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000966

upstream raw materials:

E/Z-1,3-Dichloropropene

N-tert-butoxycarbonyl-4-benzyloxy-7-cyano-1-iodo-2-naphthylamine

Downstream raw materials:

rac-5-benzyloxy-3-tert-butoxycarbonyl-1-chloromethyl-8-cyano-1,2-dihydro-3H-benz[e]indole