tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

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Chemical Name:tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide
CAS No.:476185-58-7
Molecular Formula:C₂₄H₂₄F₃N₃O₈S
Molecular Weight:571.531
Hs Code.:

Synonyms:tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

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Chemical Property of tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

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Technology Process of tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

There total 7 articles about tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 476193-03-0
C₂₉H₃₂F₃N₃O₉S

: 476185-58-7
tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide

: 476185-58-7
tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: toluene / 30 h / 90 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 20 - 60 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 40 h

5: acetyl chloride / methanol

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.03.099

Reference yield:

: 1310570-15-0
4-[[4-(3-carboxypropoxy)phenyl] sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid 1,1-dimethylethyl ester

: 476185-58-7
tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: toluene / 30 h / 90 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 20 - 60 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 40 h

5: acetyl chloride / methanol

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.03.099