(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Base Information

Chemical Name:(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane
CAS No.:637019-45-5
Molecular Formula:C₁₆H₂₀N₂O₄
Molecular Weight:304.346
Hs Code.:

Synonyms:(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Suppliers and Price of (2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

There total 3 articles about (2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: (2R,5S,7R)-1-aza-3-oxa-8-oxo-2-phenyl-7-[ethyloxycarbonyl(benzhydrylideneamino)methyl]bicyclo[3.3.0]octane

: 637019-45-5
(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Guidance literature:: With hydroxylamine hydrochloride; In ethanol; dichloromethane; for 2h; Heating;
DOI:10.1039/b303924b

Reference yield:

: 176484-87-0
(2R,5S,7S)-1-aza-3-oxa-8-oxo-2-phenyl-7-iodobicyclo[3.3.0]octane

: 637019-45-5
(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

1.2: 25.6 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 46 percent / aq. H₂NOH*HCl / ethanol; CH₂Cl₂ / 2 h / Heating

With hydroxylamine hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1039/b303924b

Reference yield:

: (3R,7aS)-6-Chloro-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 637019-45-5
(2R,5S,7R,1'S)-1-aza-3-oxa-8-oxo-2-phenyl-7-[amino(ethoxycarbonyl)methyl]bicyclo[3.3.0]octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 16 percent / NaI / acetone / 10 h / Heating

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: 25.6 percent / tetrahydrofuran / 1 h / -78 °C

3.1: 46 percent / aq. H₂NOH*HCl / ethanol; CH₂Cl₂ / 2 h / Heating

With hydroxylamine hydrochloride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1039/b303924b