(S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester

Base Information

• Chemical Name: (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester
• CAS No.: 478014-50-5
• Molecular Formula: C₄₀H₄₉N₃O₉
• Molecular Weight: 715.844
• Mol file: 478014-50-5.mol

Synonyms:(S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester

Chemical Property of (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester

There total 2 articles about (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

anthracenylmethyl chloride (24463-19-2) → (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester (478014-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium carbonate; cesium iodide / tetrahydrofuran / Heating

1.2: 56 percent / tetrahydrofuran / 18 h / Heating

2.1: 96 percent / EDCI / CH₂Cl₂ / 11 h / 20 °C

With caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium iodide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja027507p

Reference yield:

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (23978-55-4) → (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester (478014-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium carbonate; cesium iodide / tetrahydrofuran / Heating

1.2: 56 percent / tetrahydrofuran / 18 h / Heating

2.1: 96 percent / EDCI / CH₂Cl₂ / 11 h / 20 °C

With caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium iodide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja027507p

Reference yield: 84.0%

(S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbylamino-4-oxo-butyric acid methyl ester (478014-50-5) → (S)-4-(16-anthracen-9-ylmethyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-2-benzyloxycarbonylamino-4-oxo-butyric acid

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 40h;

DOI:10.1021/ja027507p

upstream raw materials:

anthracenylmethyl chloride

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane