1-(5-Amino-2-pyridinyl)-4-piperidinol

Base Information

• Chemical Name: 1-(5-Amino-2-pyridinyl)-4-piperidinol
• CAS No.: 476342-37-7
• Molecular Formula: C10H15N3O
• Molecular Weight: 193.25
• Hs Code.: 2933990090
• Mol file: 476342-37-7.mol

Synonyms:1-(5-Amino-2-pyridinyl)-4-piperidinol

Chemical Property of 1-(5-Amino-2-pyridinyl)-4-piperidinol

Chemical Property:

• Vapor Pressure: 7.67E-09mmHg at 25°C
• Refractive Index: 1.631
• Boiling Point: 448.8°Cat760mmHg
• PKA: 14.73±0.20(Predicted)
• Flash Point: 225.3°C
• PSA: 62.38000
• Density: 1.253g/cm³
• LogP: 1.27110
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Amino-2-pyridinyl)-4-piperidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Amino-2-pyridinyl)-4-piperidinol

There total 2 articles about 1-(5-Amino-2-pyridinyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

→ 1-(5-aminopyridin-2-yl)piperidin-4-ol (476342-37-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h;

Reference yield: 89.0%

1-(5-nitropyridin-2-yl)piperidin-4-ol (353258-16-9) → 1-(5-aminopyridin-2-yl)piperidin-4-ol (476342-37-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;

Reference yield:

1-(5-aminopyridin-2-yl)piperidin-4-ol (476342-37-7) + 4-(4-chlorophenyl)-1-(dimethylamino-methyleneamino)-1H-pyrrole-2-carboxylic acid (1221420-34-3) → 4-(4-chlorophenyl)-1-((dimethylamino)methyleneamino)-N-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)-1H-pyrrole-2-carboxamide (1221420-36-5)

Guidance literature:

4-(4-chlorophenyl)-1-(dimethylamino-methyleneamino)-1H-pyrrole-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

1-(5-aminopyridin-2-yl)piperidin-4-ol; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

1-(5-nitropyridin-2-yl)piperidin-4-ol

Downstream raw materials:

4-(4-chlorophenyl)-1-((dimethylamino)methyleneamino)-N-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)-1H-pyrrole-2-carboxamide

Refernces

• 1、 -. "5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF". Paragraph 1279; 1281; 1282; 1288. . Retrieved 2015/11/09.
• 2、 -. "AZOLOTRIAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS". Page/Page column 71. . Retrieved 2010/04/28.