3-{[(Furan-2-ylmethyl)amino]methyl}phenol

Base Information

• Chemical Name: 3-{[(Furan-2-ylmethyl)amino]methyl}phenol
• CAS No.: 827328-40-5
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• DSSTox Substance ID: DTXSID701261662
• Mol file: 827328-40-5.mol

Synonyms:DTXSID701261662;N-furfuryl-N-(3-hydroxybenzyl)amine;STK126687;AKOS000142486;3-{[(furan-2-ylmethyl)amino]methyl}phenol;Phenol, 3-[[(2-furanylmethyl)amino]methyl]-;827328-40-5

Chemical Property of 3-{[(Furan-2-ylmethyl)amino]methyl}phenol

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 203.094628657
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)CNCC2=CC=CO2

Technology Process of 3-{[(Furan-2-ylmethyl)amino]methyl}phenol

There total 3 articles about 3-{[(Furan-2-ylmethyl)amino]methyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H11NO2 → N-furfuryl-N-(3-hydroxybenzyl)amine (827328-40-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 50 ℃;

DOI:10.1016/j.ejmech.2008.04.011

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → N-furfuryl-N-(3-hydroxybenzyl)amine (827328-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h

2: sodium tetrahydroborate / methanol; dichloromethane / 22 h / 5 - 20 °C

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1080/10426507.2015.1135150

Reference yield:

furan-2-ylmethanamine (617-89-0) + meta-hydroxybenzaldehyde (100-83-4) → N-furfuryl-N-(3-hydroxybenzyl)amine (827328-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / 20 °C

2: sodium tetrahydroborate / methanol; dichloromethane / 22 h / 5 - 20 °C

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1134/S0022476618010067

upstream raw materials:

meta-hydroxybenzaldehyde

furan-2-ylmethanamine

Downstream raw materials:

1-(furan-2-ylmethyl)-1-(4-hydroxybenzyl)-3,3-dimethyl urea