(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Base Information

Chemical Name:(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone
CAS No.:139278-13-0
Molecular Formula:C₅₅H₉₅NO₈Si₃
Molecular Weight:982.618
Hs Code.:

(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Synonyms:(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Suppliers and Price of (4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

There total 10 articles about (4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 139277-98-8
(4S)-4-benzyl-3-<(2E,5S,7E,9E)-5-(tert-butyldimethylsiloxy)-10-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-2,7,9-decatrienoyl>-2-oxazolidinone

: 139278-13-0
(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Guidance literature:: With dimethylaluminum chloride; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/ja00064a011

Reference yield:

: 139278-09-4
(S)-1-(2-naphthyl)ethyl (3S)-4-formyl-3-(tert-butyldimethylsiloxy)butanoate

: 139278-13-0
(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / CrCl₂ / tetrahydrofuran; dioxane / 7 h / Ambient temperature

2: 78 percent / DIBAL-H / toluene / 0.75 h / -78 °C

3: 84 percent / 4-(dimethylamino)pyridine / CHCl₃ / a) RT, 4 h, b) reflux, 1.5 h

4: 69 percent / N-methylpyrrolidinone (NMP), diisopropylethylamine, cadmium chloride, tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform complex / CH₂Cl₂ / 6 h / 45 °C

5: 71 percent / Me₂AlCl / CH₂Cl₂ / 2 h / 0 - 20 °C

With 1-methyl-pyrrolidin-2-one; chromium dichloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; dimethylaluminum chloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; cadmium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja00064a011

Reference yield:

: 139278-08-3
hydrogen (3S,1'S)-1-<1'-(2-naphthyl)ethyl> 3-(tert-butyldimethylsiloxy)pentanedioate

: 139278-13-0
(4S)-4-benzyl-3-<<(2S,3aS,4R,5S,7aR)-2-(tert-butyldimethylsiloxy)-5-<(4R,6S,7R,8R,12R)-12-ethyl-7-methyl-2-oxo-6-(triethylsiloxy)-8-(triisopropylsiloxy)-1-oxacyclododec-4-yl>-3a,4,5,7a-tetrahydro-4-indanyl>carbonyl>-2-oxazolidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / BH₃*Me₂S / tetrahydrofuran / 20 h / Ambient temperature

2: oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / -70 - 0 °C

3: 80 percent / CrCl₂ / tetrahydrofuran; dioxane / 7 h / Ambient temperature

4: 78 percent / DIBAL-H / toluene / 0.75 h / -78 °C

5: 84 percent / 4-(dimethylamino)pyridine / CHCl₃ / a) RT, 4 h, b) reflux, 1.5 h

6: 69 percent / N-methylpyrrolidinone (NMP), diisopropylethylamine, cadmium chloride, tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform complex / CH₂Cl₂ / 6 h / 45 °C

7: 71 percent / Me₂AlCl / CH₂Cl₂ / 2 h / 0 - 20 °C

With 1-methyl-pyrrolidin-2-one; chromium dichloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; oxalyl dichloride; dimethylsulfide borane complex; dimethylaluminum chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; cadmium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja00064a011