(+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid

Base Information

• Chemical Name: (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid
• CAS No.: 166810-06-6
• Molecular Formula: C₂₁H₂₂N₆O₇
• Molecular Weight: 470.442

Synonyms:(+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid

Chemical Property of (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid

Chemical Property:

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Technology Process of (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid

There total 6 articles about (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(+/-)-6-Ethyl-4-(4-nitrophenyl)-2-((2-azidoethyl)oxy)methyl-5-(2-cyanocarboethoxy)-3-(1,1-dimethyl)carboethoxy-1,4-dihydropyridine (166810-04-4) → (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid (166810-06-6)

Guidance literature:

With formic acid; for 1.25h;

DOI:10.1016/S0040-4039(98)01012-0

Reference yield:

4-nitrobenzaldehdye (555-16-8) → (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid (166810-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidinium acetate / ethanol / Ambient temperature

2: 2-methyl-propan-2-ol / 5 h / Heating

3: 58 percent / formic acid / 1.25 h

With formic acid; piperdinium acetate; In ethanol; tert-butyl alcohol;

DOI:10.1016/S0040-4039(98)01012-0

Reference yield:

2-cyanoethyl propionylacetate (166811-00-3) → (+/-)-2-Ethyl-4-(4-nitrophenyl)-6-((2-azidoethyl)oxy)methyl-3-(2-cyanocarboethoxy)-1,4-dihydropyridine-5-carboxylic Acid (166810-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidinium acetate / ethanol / Ambient temperature

2: 2-methyl-propan-2-ol / 5 h / Heating

3: 58 percent / formic acid / 1.25 h

With formic acid; piperdinium acetate; In ethanol; tert-butyl alcohol;

DOI:10.1016/S0040-4039(98)01012-0

upstream raw materials:

(+/-)-6-Ethyl-4-(4-nitrophenyl)-2-((2-azidoethyl)oxy)methyl-5-(2-cyanocarboethoxy)-3-(1,1-dimethyl)carboethoxy-1,4-dihydropyridine

4-nitrobenzaldehdye

2-cyanoethyl propionylacetate

Downstream raw materials:

6-(2-Azido-ethoxymethyl)-5-[3-(4,4-diphenyl-piperidin-1-yl)-propylcarbamoyl]-2-ethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid

6-(2-Azido-ethoxymethyl)-5-[3-(4,4-diphenyl-piperidin-1-yl)-propylcarbamoyl]-2-ethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester

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