Technology Process of 2,2,2-trifluoro-N-[2-(2-iodophenyl)ethyl]-N-(prop-2-en-1-yl)acetamide
There total 3 articles about 2,2,2-trifluoro-N-[2-(2-iodophenyl)ethyl]-N-(prop-2-en-1-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetra(n-butyl)ammonium hydrogensulfate;
In
toluene;
at 60 ℃;
for 0.0833333h;
Large scale reaction;
DOI:10.1002/ejoc.200900028
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice
2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / toluene / 0.17 h / 20 °C
2.2: 0.33 h / 60 °C
With
tetra(n-butyl)ammonium hydrogensulfate; triethylamine; potassium hydroxide;
In
dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: borane-THF / tetrahydrofuran / 2 h / Reflux
2.1: triethylamine / dichloromethane / 20 °C / Cooling with ice
3.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / toluene / 0.17 h / 20 °C
3.2: 0.33 h / 60 °C
With
borane-THF; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; toluene;