5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

Base Information

Chemical Name:5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole
CAS No.:1026190-74-8
Molecular Formula:C₂₁H₁₇FO₂S
Molecular Weight:352.429
Hs Code.:

Synonyms:5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

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Chemical Property of 5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

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Technology Process of 5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

There total 5 articles about 5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 1026190-74-8
5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / bromine; acetic acid; iodine / CS₂ / 20 °C

2: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

3: tetrahydrofuran / 2.17 h / 0 - 20 °C

4: 71 percent / H₂ / Pd/C / ethanol; ethyl acetate / 2068.59 Torr

5: [bis(2-methoxyethyl)amino]sulfur trioxide; SbCl₃ / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(2-methoxyethyl)amino]sulfur trioxide; hydrogen; bromine; iodine; antimony(III) chloride; sodium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; carbon disulfide; ethanol; dichloromethane; ethyl acetate; 2: Suzuki coupling / 3: Grignard reaction;
DOI:10.1021/jm030268b

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 1026190-74-8
5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

2: tetrahydrofuran / 2.17 h / 0 - 20 °C

3: 71 percent / H₂ / Pd/C / ethanol; ethyl acetate / 2068.59 Torr

4: [bis(2-methoxyethyl)amino]sulfur trioxide; SbCl₃ / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(2-methoxyethyl)amino]sulfur trioxide; hydrogen; antimony(III) chloride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1: Suzuki coupling / 2: Grignard reaction;
DOI:10.1021/jm030268b

Reference yield:

: 445039-73-6
6-(4-methylthiophenyl)-2H-benzo[d]1,3-dioxolane-5-carbaldehyde

: 1026190-74-8
5-benzyl-6-(4-fluoromethylsulfanyl-phenyl)-benzo[1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2.17 h / 0 - 20 °C

2: 71 percent / H₂ / Pd/C / ethanol; ethyl acetate / 2068.59 Torr

3: [bis(2-methoxyethyl)amino]sulfur trioxide; SbCl₃ / CH₂Cl₂ / 20 °C

With [bis(2-methoxyethyl)amino]sulfur trioxide; hydrogen; antimony(III) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1: Grignard reaction;
DOI:10.1021/jm030268b