methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Base Information

• Chemical Name: methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate
• CAS No.: 1414931-73-9
• Molecular Formula: C₁₇H₁₃F₃O₄
• Molecular Weight: 338.283
• Mol file: 1414931-73-9.mol

Synonyms:methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Chemical Property of methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

There total 1 articles about methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-methoxy-4-trifluoromethylbenzaldehyde (1414931-72-8) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (1414931-73-9)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In toluene; at 80 ℃; for 16h;

Reference yield:

methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (1414931-73-9) + 3-chloro-4-(4-chlorophenyl)benzenamine (138588-57-5) → methyl 2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (1414931-74-0)

Guidance literature:

methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate; 3-chloro-4-(4-chlorophenyl)benzenamine; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

With water; sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

methyl 2'-formyl-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (1414931-73-9) → 3-(2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoic acid (1414931-41-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

With water; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-6-methoxy-4-trifluoromethylbenzaldehyde

4-methoxycarbonylphenylboronic acid

Downstream raw materials:

methyl 2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

3-(2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoic acid

Ethyl 3-(2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid