Technology Process of 2-phenylbenzofuran-6-yl 2-octynoate
There total 3 articles about 2-phenylbenzofuran-6-yl 2-octynoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-hydroxy-2-phenylbenzofuran; oct-2-ynoic acid;
With
dmap;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
DOI:10.3987/COM-12-S(N)36
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere
2.1: dmap / dichloromethane / 0.08 h / 0 °C
2.2: 3 h / 0 - 20 °C
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-S(N)36
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Iodine monochloride / diethyl ether / 3 h / 20 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere
3.1: dmap / dichloromethane / 0.08 h / 0 °C
3.2: 3 h / 0 - 20 °C
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; triethylamine;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-S(N)36
