Technology Process of acetic acid 1-(4-methoxybenzyl)-4-methyl-2-oxo-1,2,5,10-tetrahydrobenzo[g]quinolin-3-yl ester
There total 7 articles about acetic acid 1-(4-methoxybenzyl)-4-methyl-2-oxo-1,2,5,10-tetrahydrobenzo[g]quinolin-3-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
xylene;
for 1.5h;
Heating;
DOI:10.1021/jo9915729
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 76 percent / PBr3; pyridine / benzene / 0.17 h / 0 °C
2.1: 94 percent / dimethylsulfoxide / 0.33 h / 20 °C
3.1: 93 percent / KOH / aq. ethanol / 15 h / Heating
4.1: oxalyl chloride / benzene; dimethylformamide / 2 h
4.2: 87 percent / CH2Cl2 / 0.33 h / 20 °C
5.1: 87 percent / benzene / 12 h / Heating
6.1: 96 percent / sodium periodate / methanol; H2O / 3 h
7.1: 68 percent / p-toluenesulfonic acid / xylene / 1.5 h / Heating
With
pyridine; potassium hydroxide; sodium periodate; oxalyl dichloride; phosphorus tribromide; toluene-4-sulfonic acid;
In
methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; xylene; benzene;
1.1: Bromination / 2.1: Substitution / 3.1: Hydrolysis / 4.1: Substitution / 4.2: Acylation / 5.1: Acylation / 6.1: Oxidation / 7.1: Cycloaddition;
DOI:10.1021/jo9915729
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 94 percent / dimethylsulfoxide / 0.33 h / 20 °C
2.1: 93 percent / KOH / aq. ethanol / 15 h / Heating
3.1: oxalyl chloride / benzene; dimethylformamide / 2 h
3.2: 87 percent / CH2Cl2 / 0.33 h / 20 °C
4.1: 87 percent / benzene / 12 h / Heating
5.1: 96 percent / sodium periodate / methanol; H2O / 3 h
6.1: 68 percent / p-toluenesulfonic acid / xylene / 1.5 h / Heating
With
potassium hydroxide; sodium periodate; oxalyl dichloride; toluene-4-sulfonic acid;
In
methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; xylene; benzene;
1.1: Substitution / 2.1: Hydrolysis / 3.1: Substitution / 3.2: Acylation / 4.1: Acylation / 5.1: Oxidation / 6.1: Cycloaddition;
DOI:10.1021/jo9915729
