2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol

Base Information

Chemical Name:2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol
CAS No.:461451-35-4
Molecular Formula:C9H11N3O
Molecular Weight:177.206
Hs Code.:
ChEMBL ID:CHEMBL382694
DSSTox Substance ID:DTXSID10466830
Nikkaji Number:J2.215.385D
Wikidata:Q82293477
Mol file:461451-35-4.mol

Synonyms:461451-35-4;2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol;2-(imidazo[1,2-a]pyrimidin-7-yl)propan-2-ol;CHEMBL382694;SCHEMBL5769993;DTXSID10466830;WIFLLVVTSRUGNM-UHFFFAOYSA-N;AKOS006290342;AB49356;2-(imidazo[1,2-alpha]pyrimidin-7-yl)propan-2-ol

Suppliers and Price of 2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-IMIDAZO[1,2-A]PYRIMIDIN-7-YL-PROPAN-2-OL 95.00%
5MG
$ 504.78

Total 6 raw suppliers

Chemical Property of 2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol

Chemical Property:

PSA：50.42000
LogP:0.95670
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:177.090211983
Heavy Atom Count:13
Complexity:195

Purity/Quality:

98%min ^*data from raw suppliers

2-IMIDAZO[1,2-A]PYRIMIDIN-7-YL-PROPAN-2-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C1=NC2=NC=CN2C=C1)O

Technology Process of 2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol

There total 4 articles about 2-Imidazo[1,2-a]pyrimidin-7-yl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 463335-45-7
acetic acid 4,4-diethoxy-1,1-dimethyl-2-oxo-butyl ester

: 1450-93-7,36946-29-9,42383-61-9
2-aminoimidazole hemisulfate

: 461451-35-4
2-(imidazo[1,2-a]pyrimidin-7-yl)propan-2-ol

: 2-imidazo[1,2-a]pyrimidin-5-yl-propan-2-ol

Guidance literature:: 2-aminoimidazole hemisulfate; With ethanol; sodium methylate; at 24 - 60 ℃; for 1h;

acetic acid 4,4-diethoxy-1,1-dimethyl-2-oxo-butyl ester; In ethanol; at 45 - 60 ℃; for 4h;
DOI:10.1021/jo050741o

Reference yield:

: 10235-71-9
3-Acetoxy-3-methyl-2-butanon

: 461451-35-4
2-(imidazo[1,2-a]pyrimidin-7-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: BF₃*Et₂O / CH₂Cl₂ / 0.5 h / -40 - 0 °C

1.2: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / -78 - 20 °C

2.1: NaOMe / ethanol / 8 h / Heating

With boron trifluoride diethyl etherate; sodium methylate; In ethanol; dichloromethane;
DOI:10.1021/jm051065l