1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea

Base Information

• Chemical Name: 1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea
• CAS No.: 945992-97-2
• Molecular Formula: C₄₂H₅₁Cl₂N₅O₅Si
• Molecular Weight: 804.889

Synonyms:1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea

Chemical Property of 1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea

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Technology Process of 1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea

There total 1 articles about 1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea (945992-97-2)

Guidance literature:

Reference yield: 93.7%

1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea (945992-97-2) + 3-[4-(2-aminomethyl-benzyloxy)-3-chloro-6-methyl-2-oxo-2H-pyridin-1-yl]-4-methyl-benzoic acid methyl ester (945995-96-0) → 3-[4-(2-{3-[5-tert-butyl-2-(4-hydroxy-phenyl)-2H-pyrazol-3-yl]-ureidomethyl}-benzyloxy)-3-chloro-6-methyl-2-oxo-2H-pyridin-1-yl]-4-methyl-benzoic acid methyl ester

Guidance literature:

phosgene; 3-[4-(2-aminomethyl-benzyloxy)-3-chloro-6-methyl-2-oxo-2H-pyridin-1-yl]-4-methyl-benzoic acid methyl ester; With sodium hydrogencarbonate; In dichloromethane; water; toluene; at 0 ℃; for 0.25 - 0.333333h;

1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea; In tetrahydrofuran; dichloromethane; toluene; at 20 ℃;

Reference yield:

1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea (945992-97-2) → 1-(2-((1-(2-methoxybenzyl)-3-chloro-1,2-dihydro-6-methyl-2-oxopyridin-4-yloxy)methyl)benzyl)-3-(3-tert-butyl-1-(4-chloro-3-hydroxyphenyl)-1H-pyrazol-5-yl)urea

Guidance literature:

1-[3-tert-butyl-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-4-chlorophenyl)-1H-pyrazol-5-yl]-3-[2-({[3-chloro-1-(2-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]urea; With methanol; potassium fluoride; at 20 ℃; for 1.5h;

With hydrogenchloride; water;

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