1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)

Base Information

Chemical Name:1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)
CAS No.:461640-97-1
Molecular Formula:C12H17NO
Molecular Weight:191.273
Hs Code.:
Mol file:461640-97-1.mol

Synonyms:1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)

Suppliers and Price of 1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)

Chemical Property:

PSA：46.25000
LogP:2.42710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI)

There total 11 articles about 1H-Inden-2-ol,1-amino-2,3-dihydro-7-(1-methylethyl)-,(1S,2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 676121-67-8
2-isopropyl-6,6a-dihydro-1aH-1-oxa-cyclopropa[a]indene

: 461640-97-1
(1S,2R)-(-)-cis-1-amino-7-isopropylindan-2-ol

Guidance literature:: 2-isopropyl-6,6a-dihydro-1aH-1-oxa-cyclopropa[a]indene; With sulfuric acid; acetonitrile; In hexane; at 20 ℃; for 1h;

With water; at 100 ℃; for 2h;
DOI:10.1021/jo049381f

Reference yield:

: 65651-63-0,38836-21-4
4-hydroxy-5-methyl-hexan-2-one

: 461640-97-1
(1S,2R)-(-)-cis-1-amino-7-isopropylindan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 71 percent / p-TsOH*H₂O; Na₂SO₄ / benzene / 5 h / 90 °C

2.1: 79 percent / LiN(TMS)2 / tetrahydrofuran; toluene / 1.17 h / -78 - 20 °C

3.1: 2,5-di-tert-butylhydroquinone / benzene / 56 h / 200 °C

4.1: p-TsOH*H₂O / acetone / 0.5 h / 20 °C

5.1: 75 percent / p-cymene / Pd/C / 45 h / 200 °C

6.1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 20 °C

7.1: 87 percent / NaBH₄; NiCl₂*6H₂O / methanol / 3 h / 0 - 20 °C

8.1: 100 percent / pTsOH*H₂O / benzene / 0.67 h / 20 - 100 °C

9.1: 86 percent / mCPBA; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; N-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / -78 °C

10.1: H₂SO₄; acetonitrile / hexane / 1 h / 20 °C

10.2: 39 percent / H₂O / 2 h / 100 °C

With sodium tetrahydroborate; 4-methylisopropylbenzene; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; sodium sulfate; 3-chloro-benzenecarboperoxoic acid; acetonitrile; nickel dichloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; toluene; benzene; 3.1: Diels-Alder reaction / 9.1: Jacobsen reaction / 10.1: Ritter reaction;
DOI:10.1021/jo049381f

Reference yield:

: 1669-43-8,5166-53-0,1821-29-0
(E)-4-isopropylbut-3-en-2-one

: 461640-97-1
(1S,2R)-(-)-cis-1-amino-7-isopropylindan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 79 percent / LiN(TMS)2 / tetrahydrofuran; toluene / 1.17 h / -78 - 20 °C

2.1: 2,5-di-tert-butylhydroquinone / benzene / 56 h / 200 °C

3.1: p-TsOH*H₂O / acetone / 0.5 h / 20 °C

4.1: 75 percent / p-cymene / Pd/C / 45 h / 200 °C

5.1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 20 °C

6.1: 87 percent / NaBH₄; NiCl₂*6H₂O / methanol / 3 h / 0 - 20 °C

7.1: 100 percent / pTsOH*H₂O / benzene / 0.67 h / 20 - 100 °C

8.1: 86 percent / mCPBA; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; N-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / -78 °C

9.1: H₂SO₄; acetonitrile / hexane / 1 h / 20 °C

9.2: 39 percent / H₂O / 2 h / 100 °C

With sodium tetrahydroborate; 4-methylisopropylbenzene; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid; acetonitrile; nickel dichloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; toluene; benzene; 2.1: Diels-Alder reaction / 8.1: Jacobsen reaction / 9.1: Ritter reaction;
DOI:10.1021/jo049381f