(S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

Base Information

• Chemical Name: (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester
• CAS No.: 175918-13-5
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.343
• Mol file: 175918-13-5.mol

Synonyms:(S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

Chemical Property of (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

There total 5 articles about (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester (175918-12-4) → (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester (175918-13-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.333333h; Yield given;

DOI:10.1021/jo952074c

Reference yield:

4-(3-Hydroxypropyl)pyridine (2629-72-3) → (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester (175918-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂ / 14 h

2: TBAF / tetrahydrofuran / 0.33 h / 0 °C

With dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo952074c

Reference yield:

L-3-phenyllactic acid (20312-36-1) → (S)-2-Hydroxy-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester (175918-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: DBU / CH₂Cl₂ / 0.33 h / 0 °C

2: (COCl)2, DMF / CH₂Cl₂ / 2 h

3: DMAP / CH₂Cl₂ / 14 h

4: TBAF / tetrahydrofuran / 0.33 h / 0 °C

With dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo952074c

upstream raw materials:

(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

4-(3-Hydroxypropyl)pyridine

L-3-phenyllactic acid

(2S)-2-(tert-butyldimethylsilyloxy)-3-phenylpropanoyl chloride

Downstream raw materials:

(S)-2-({(R)-1-[(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylamino]-2-phenyl-ethyl}-methoxy-phosphinoyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

(S)-2-({(R)-1-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylamino]-2-phenyl-ethyl}-methoxy-phosphinoyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

(S)-2-({(R)-1-[2-((R)-2-Benzyloxycarbonylamino-propionylamino)-acetylamino]-2-phenyl-ethyl}-methoxy-phosphinoyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester

(S)-2-({(R)-1-[2-((S)-2-Benzyloxycarbonylamino-propionylamino)-acetylamino]-2-phenyl-ethyl}-methoxy-phosphinoyloxy)-3-phenyl-propionic acid 3-pyridin-4-yl-propyl ester