Technology Process of (2S,3R,5R,6R)-2-(3'-benzyloxy)propyl-3-acetyl-5-ethyl-6-propylpiperidine
There total 10 articles about (2S,3R,5R,6R)-2-(3'-benzyloxy)propyl-3-acetyl-5-ethyl-6-propylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
for 3h;
Heating;
DOI:10.1021/jo0341261
- Guidance literature:
-
With
hydrogen; acetic acid;
platinum(IV) oxide;
at 20 ℃;
for 1h;
atmospheric pressure;
DOI:10.1021/jo0341261
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 85 percent / sulfuric acid / 72 h / 20 °C
2.1: n-BuLi / toluene / 1 h
2.2: toluene; tetrahydrofuran / 3.5 h / -78 - -40 °C
2.3: 67 percent / 2,6-di-tert-butyl-4-methylphenol / tetrahydrofuran; toluene / 1 h / -78 - 20 °C
3.1: LiAlH4 / tetrahydrofuran / 12 h / Heating
4.1: 1.8 g / H2 / 20 percent Pd(OH)2/C / methanol / 12 h / 50 °C / 38000 Torr
5.1: 88 percent / K2CO3 / acetonitrile; H2O / 10 h / 50 °C
6.1: triphenylphosphine; iodine; imidazole / CH2Cl2 / 2 h / 0 - 20 °C
7.1: 263 mg / triethylamine / acetonitrile / 15 h / Heating
8.1: 22 percent / acetic acid; H2 / PtO2 / 1 h / 20 °C / atmospheric pressure
With
1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; hydrogen; iodine; potassium carbonate; acetic acid; triethylamine; triphenylphosphine;
platinum(IV) oxide; palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
2.2: Michael addition / 5.1: Michael addition;
DOI:10.1021/jo0341261
