2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

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Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide
CAS No.:1285515-67-4
Molecular Formula:C₂₇H₂₈FN₅O₄
Molecular Weight:505.549
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

There total 5 articles about 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 354795-62-3
3-methylisoxazol-4-ylamine

: 1285517-46-5
2-{[(4-fluorophenyl)methyl]oxy}-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzoic acid

: 1285515-67-4
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1285515-67-4
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / Reflux

2.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.5 h / 120 °C / microwave irradiation; Sealed vial

3.1: water; lithium hydroxide / tetrahydrofuran / 4 h / Reflux

3.2: pH 1

4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With potassium phosphate; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1285517-41-0
methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-iodobenzoate

: 1285515-67-4
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.5 h / 120 °C / microwave irradiation; Sealed vial

2.1: water; lithium hydroxide / tetrahydrofuran / 4 h / Reflux

2.2: pH 1

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With potassium phosphate; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;