Technology Process of (Z)-2-acetamido-N-benzyl-3-methoxyacrylamide
There total 5 articles about (Z)-2-acetamido-N-benzyl-3-methoxyacrylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(Z)-2-acetylamino-3-methoxy-2-propenoic acid;
With
4-methyl-morpholine;
In
tetrahydrofuran; dichloromethane;
at -40 ℃;
for 0.333333h;
With
isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane;
at -40 ℃;
for 0.333333h;
benzylamine;
In
tetrahydrofuran; dichloromethane;
at -40 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / acetonitrile / 15 - 20 °C
2.1: hydrogenchloride / 4 h / 0 - 20 °C
3.1: potassium carbonate / acetone / 0.5 h / 0 °C
3.2: 6 h / 0 °C
4.1: potassium tert-butylate / water; tert-butyl methyl ether / 5 h / 0 - 20 °C
5.1: 4-methyl-morpholine / dichloromethane; tetrahydrofuran / 0.33 h / -40 °C
5.2: 0.33 h / -40 °C
5.3: 1 h / -40 °C
With
4-methyl-morpholine; hydrogenchloride; potassium tert-butylate; water; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / water; tert-butyl methyl ether / 5 h / 0 - 20 °C
2.1: 4-methyl-morpholine / dichloromethane; tetrahydrofuran / 0.33 h / -40 °C
2.2: 0.33 h / -40 °C
2.3: 1 h / -40 °C
With
4-methyl-morpholine; potassium tert-butylate;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water;