3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

Base Information

Chemical Name:3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine
CAS No.:1313410-01-3
Molecular Formula:C₂₁H₂₃N₅O
Molecular Weight:361.447
Hs Code.:

Synonyms:3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

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Chemical Property of 3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

Chemical Property:

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Technology Process of 3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

There total 8 articles about 3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313409-99-2
1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-4-nitro-3-vinyl-1H-indazole

: 1313410-01-3
3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

Guidance literature:: With hydrogen; 20% palladium hydroxide-activated charcoal; In methanol; dichloromethane; for 3h; Inert atmosphere;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1313410-01-3
3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 38 h / 5 - 25 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide

3: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; isopropyl alcohol / 16 h / 80 °C

4: hydrogen / 20% palladium hydroxide-activated charcoal / methanol; dichloromethane / 3 h / Inert atmosphere

With hydrogen; iodine; potassium carbonate; triethylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 885521-22-2
3-iodo-4-nitro-1H-indazole

: 1313410-01-3
3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; isopropyl alcohol / 16 h / 80 °C

3: hydrogen / 20% palladium hydroxide-activated charcoal / methanol; dichloromethane / 3 h / Inert atmosphere

With hydrogen; potassium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;