Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

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Chemical Name:Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester
CAS No.:208336-18-9
Molecular Formula:C₄₇H₄₈N₅O₁₁P
Molecular Weight:889.899
Hs Code.:

Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

Synonyms:Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

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Chemical Property of Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

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Technology Process of Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

There total 6 articles about Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 208336-16-7
Phosphoric acid (2S,4S,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

: 208336-18-9
Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

Guidance literature:: With pyridine; at 20 ℃; for 15h;
DOI:10.1016/S0040-4020(98)00237-3

Reference yield:

: 105291-41-6
1-[3'-deoxy-4',6'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-β-D-psicofuranosyl]uracil

: 208336-18-9
Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tetrazole, 2.) I₂ / 1.) CH₃CN, 20 deg C, 1.5 h, 2.) THF, H₂O, Py, 20 deg C, 1.25 h.

2: 83 percent / TBAF*H₂O / tetrahydrofuran / 0.08 h / 0 °C

3: 83 percent / Py / 15 h / 20 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; iodine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00237-3

Reference yield:

: 194785-99-4
2-(N-(2-hydroxyethyl)-N-methyl)aminophenazine

: 208336-18-9
Phosphoric acid (2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-2-ylmethyl ester methyl ester 2-(methyl-phenazin-2-yl-amino)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / diisopropylethylamine / tetrahydrofuran / 1.5 h / 20 °C

2: 1.) tetrazole, 2.) I₂ / 1.) CH₃CN, 20 deg C, 1.5 h, 2.) THF, H₂O, Py, 20 deg C, 1.25 h.

3: 83 percent / TBAF*H₂O / tetrahydrofuran / 0.08 h / 0 °C

4: 83 percent / Py / 15 h / 20 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; iodine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00237-3