Technology Process of N-((3S,5R)-5-fluoropiperidin-3-yl)-2-methoxybenzamide
There total 10 articles about N-((3S,5R)-5-fluoropiperidin-3-yl)-2-methoxybenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: triethylamine / dichloromethane / 8 h / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
3: sodium azide / N,N-dimethyl-formamide / 8 h / 65 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere
5: 1,4-dioxane / 20 h / 20 °C / Inert atmosphere
6: diethylamino-sulfur trifluoride / tetrahydrofuran / 13 h / 0 - 20 °C / Inert atmosphere
7: hydrogenchloride / methanol; water; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
8: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
9: palladium 10% on activated carbon; formic acid; piperidine / methanol; water / 1 h / 55 °C / Inert atmosphere; Microwave irradiation
With
piperidine; hydrogenchloride; lithium aluminium tetrahydride; formic acid; sodium azide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201302423
- Guidance literature:
-
With
piperidine; formic acid; palladium 10% on activated carbon;
In
methanol; water;
at 55 ℃;
for 1h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1002/chem.201302423
- Guidance literature:
-
Multi-step reaction with 10 steps
1: thionyl chloride / 24 h / 0 °C / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 8 h / Inert atmosphere; Reflux
3: triethylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
4: sodium azide / N,N-dimethyl-formamide / 8 h / 65 °C / Inert atmosphere
5: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere
6: 1,4-dioxane / 20 h / 20 °C / Inert atmosphere
7: diethylamino-sulfur trifluoride / tetrahydrofuran / 13 h / 0 - 20 °C / Inert atmosphere
8: hydrogenchloride / methanol; water; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
9: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
10: palladium 10% on activated carbon; formic acid; piperidine / methanol; water / 1 h / 55 °C / Inert atmosphere; Microwave irradiation
With
piperidine; hydrogenchloride; lithium aluminium tetrahydride; formic acid; thionyl chloride; sodium azide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201302423
