t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

Base Information

Chemical Name:t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate
CAS No.:444646-10-0
Molecular Formula:C₂₅H₃₁F₃N₂O₅
Molecular Weight:496.527
Hs Code.:

Synonyms:t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

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Chemical Property of t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

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Technology Process of t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

There total 7 articles about t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070873-42-5
t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-(methylsulfonyloxy)propyl]-N-methylcarbamate

: 444646-10-0
t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

Guidance literature:: 4-hydroxybenzotrifluoride; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-(methylsulfonyloxy)propyl]-N-methylcarbamate; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 402-45-9
4-hydroxybenzotrifluoride

: 444646-09-7
N-[1-(3-dimethylcarbamoyloxyphenyl)-3-hydroxypropyl]-N-methylcarbamic acid tert-butyl ester

: 444646-10-0
t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 444646-10-0
t-butyl N-[1-[(3-dimethylcarbamoyloxy)phenyl]-3-[(4-trifluoromethyl)phenoxy]propyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 58 percent / ethanol / 2 h / 90 °C

2: 6.04 g / sulfuric acid / 6 h / 80 °C

3: 8.53 g / tetrahydrofuran / 12 h / 20 °C

4: 88 percent / K₂CO₃ / dimethylformamide / 3 h / 20 °C

5: 61 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / -20 - -10 °C

6: PPh₃; diethyl azodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction;