Technology Process of 3-hydroxy-4',5,6,8-tetramethoxyflavone
There total 4 articles about 3-hydroxy-4',5,6,8-tetramethoxyflavone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / dimethylformamide / 2 h / 140 - 150 °C
2: 90 percent / AlCl3 / acetonitrile / 3 h / 60 °C
3: 1.) p-methoxybenzoic anhydride, potassium p-methoxybenzoate, 2.) KOH / 1.) from 170 deg C to 180 deg C, 10 h, 2.) methanol, water, reflux, 30 min.
With
potassium hydroxide; aluminium trichloride; potassium 4-methoxybenzoate; p-Methoxybenzoic anhydride;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/bcsj.55.2933
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / CuBr2 / CHCl3; ethyl acetate / 24 h / Ambient temperature
2: 81 percent / dimethylformamide / 2 h / 140 - 150 °C
3: 90 percent / AlCl3 / acetonitrile / 3 h / 60 °C
4: 1.) p-methoxybenzoic anhydride, potassium p-methoxybenzoate, 2.) KOH / 1.) from 170 deg C to 180 deg C, 10 h, 2.) methanol, water, reflux, 30 min.
With
potassium hydroxide; aluminium trichloride; potassium 4-methoxybenzoate; p-Methoxybenzoic anhydride; copper(ll) bromide;
In
chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/bcsj.55.2933
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / AlCl3 / acetonitrile / 3 h / 60 °C
2: 1.) p-methoxybenzoic anhydride, potassium p-methoxybenzoate, 2.) KOH / 1.) from 170 deg C to 180 deg C, 10 h, 2.) methanol, water, reflux, 30 min.
With
potassium hydroxide; aluminium trichloride; potassium 4-methoxybenzoate; p-Methoxybenzoic anhydride;
In
acetonitrile;
DOI:10.1246/bcsj.55.2933
