methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

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Chemical Name:methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate
CAS No.:1427803-75-5
Molecular Formula:C₂₉H₂₆N₈O₉
Molecular Weight:630.574
Hs Code.:

methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

Synonyms:methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

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Chemical Property of methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

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Technology Process of methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

There total 4 articles about methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1427803-71-1
methyl (S)-2-(2-azidoacetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

: 1427803-72-2
benzyl [2-oxo-1-(prop-2-yn-1-yl)-1,2-dihydropyrimidin-4-yl]carbamate

: 1427803-75-5
methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

Guidance literature:: With copper(ll) sulfate pentahydrate; ascorbic acid; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1055/s-0032-1317689

Reference yield:

: 1067639-63-7
O-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N-(triphenylmethyl)-L-serine methyl ester

: 1427803-75-5
methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetyl chloride / methanol / 1 h / 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 0.17 h / 20 °C

2.2: 17 h

3.1: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide / 18 h / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; ascorbic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317689

Reference yield:

: 1427803-60-8
O-phthalimido-L-serine methyl ester hydrochloride

: 1427803-75-5
methyl (S)-2-(2-{4-[(4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl)methyl]-1H-1,2,3-triazol-1-yl}acetamido)-3-[(1,3-dioxoisoindolin-2-yl)oxy]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 0.17 h / 20 °C

1.2: 17 h

2.1: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide / 18 h / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ascorbic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317689