1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

Base Information

Chemical Name:1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline
CAS No.:1361333-89-2
Molecular Formula:C₂₅H₂₆FN₅O₄S
Molecular Weight:511.577
Hs Code.:

Synonyms:1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

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Chemical Property of 1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

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Technology Process of 1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

There total 3 articles about 1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1361333-84-7
C₂₃H₂₄FN₅O₃

: 68-11-1
mercaptoacetic acid

: 1361333-89-2
1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

Guidance literature:: With zinc(II) chloride; In tetrahydrofuran; for 7h; Inert atmosphere; Reflux;
DOI:10.2174/1570180815666171229150032

Reference yield:

: 70458-96-7
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

: 1361333-89-2
1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 5 h / Reflux

2: hydrazine hydrate / methanol / 8 h / Reflux

3: acetic acid / ethanol / Reflux

4: zinc(II) chloride / 1,4-dioxane / Reflux

With sulfuric acid; hydrazine hydrate; acetic acid; zinc(II) chloride; In 1,4-dioxane; methanol; ethanol;

Reference yield:

: 74011-47-5
ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

: 1361333-89-2
1-ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-[2'-(p-hydroxyphenyl)-4'-oxo-1',3'-thiazolidin-3'-ylaminocarbonyl]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 8 h / Reflux

2: acetic acid / ethanol / Reflux

3: zinc(II) chloride / 1,4-dioxane / Reflux

With hydrazine hydrate; acetic acid; zinc(II) chloride; In 1,4-dioxane; methanol; ethanol;