(2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol

Base Information

• Chemical Name: (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol
• CAS No.: 790662-58-7
• Molecular Formula: C₂₄H₃₄O₄S₂
• Molecular Weight: 450.664

Synonyms:(2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol

Chemical Property of (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol

Chemical Property:

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Technology Process of (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol

There total 10 articles about (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S,3R,5R,2'S,1''R)-1''-{(3-(dimethylphenylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)}prop-2''-yn-1''-ol (790662-56-5) → (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol (790662-58-7) + (2S,3R,5R,2'S,1''R)-1''-(3-(hydroxydimethylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol (790662-57-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 85 ℃; for 24h;

DOI:10.1021/ol048381z

Reference yield: 90.0%

(2S,3R,5R,1'R,2''S)-2-[1'-(tert-butyldimethylsilanyloxy)-3'-(triethylsilanyl)prop-2'-ynyl]-3-(dimethylphenylsilanyl)-5-{2-[3''-(4-methoxybenzyloxy)-2''-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran (790662-67-8) → (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol (790662-58-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 22h;

DOI:10.1021/ol0506821

Reference yield:

(2S,3R,5R,2'S,1''R)-1''-(3-(hydroxydimethylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol (790662-57-6) → (2S,3R,5R,2'S,1''R)-1''-(5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol (790662-58-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/ol048381z

upstream raw materials:

(2S,3R,5R,2'S,1''R)-1''-(3-(hydroxydimethylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)prop-2''-yn-1''-ol

(2S,3R,5R,2'S,1''R)-1''-{(3-(dimethylphenylsilanyl)-5-{2-[3'-(4-methoxybenzyloxy)-2'-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2-yl)}prop-2''-yn-1''-ol

(2S,3R,5R,1'R,2''S)-2-[1'-(tert-butyldimethylsilanyloxy)-3'-(triethylsilanyl)prop-2'-ynyl]-3-(dimethylphenylsilanyl)-5-{2-[3''-(4-methoxybenzyloxy)-2''-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran

(S)-2-[3-(4-methoxybenzyloxy)-2-methylpropyl][1,3]dithiane

Downstream raw materials:

(1R,2'R,5'R,2''S)-tert-butyl[1-(5'-{2-[3''-(4-methoxybenzyloxy)-2''-methylpropyl][1,3]dithian-2-ylmethyl}tetrahydrofuran-2'-yl)prop-2-ynyloxy]dimethylsilane

(1S,3S,4R,1'S,2''R,5''R,1'''R,E)-benzoic acid 1-[2'-(2-{5''-[1'''-(tert-butyldimethylsilyloxy)-3'''-iodoallyl]tetrahydrofuran-2''-ylmethyl}-[1,3]dithian-2-yl)-1'-methylethyl]-3-hydroxy-5-(4-methoxybenzyloxy)-4-methyl-3-(triisopropylsilyloxy)pentyl ester

(1S,3S,4R,1'S,2''R,5''R,1'''R)-benzoic acid 1-[2'-(2-{5''-[1'''-(tert-butyldimethylsilanyloxy)prop-2'''-ynyl]tetrahydrofuran-2''-ylmethyl}-[1,3]dithian-2-yl)-1'-methylethyl]-3-hydroxy-5-(4-methoxybenzyloxy)-4-methyl-3-(triisopropylsilyloxy)pentyl ester

(2R,5S,6S,2'R,5'R,1''R)-7-(2-{5'-[1''-(tert-butyldimethylsilanyloxy)prop-2''-ynyl]tetrahydrofuran-2'-ylmethyl}-[1,3]dithian-2-yl)-5-hydroxy-1-(4-methoxybenzyloxy)-2,6-dimethylheptan-3-one

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