Technology Process of 3-bromo-6-(carboxymethyl)-2,4-dimethoxybenzoic acid (4-bromo-3,5-dimethoxyhomophthalic acid)
There total 9 articles about 3-bromo-6-(carboxymethyl)-2,4-dimethoxybenzoic acid (4-bromo-3,5-dimethoxyhomophthalic acid) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol; water;
for 1h;
Reflux;
Inert atmosphere;
DOI:10.1016/j.tet.2014.01.009
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 8.25 h / 0 - 20 °C / Inert atmosphere
2: phosphorus tribromide / benzene / 4 h / Inert atmosphere
3: potassium cyanide / ethanol; water / 2 h / Reflux; Inert atmosphere
4: potassium hydroxide / water; 1,4-dioxane; methanol / 48 h / 110 °C / Inert atmosphere
5: sulfuric acid / methanol / 8 h / Reflux; Inert atmosphere
6: trichlorophosphate / N,N-dimethyl-formamide / 55 - 100 °C / Inert atmosphere
7: hydroxylamine hydrochloride; dihydrogen peroxide; hydrogenchloride / acetonitrile / 5 h / 80 °C / Inert atmosphere
8: potassium hydroxide / ethanol; water / 1 h / Reflux; Inert atmosphere
With
hydrogenchloride; potassium cyanide; lithium aluminium tetrahydride; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; phosphorus tribromide; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.tet.2014.01.009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: phosphorus tribromide / benzene / 4 h / Inert atmosphere
2: potassium cyanide / ethanol; water / 2 h / Reflux; Inert atmosphere
3: potassium hydroxide / water; 1,4-dioxane; methanol / 48 h / 110 °C / Inert atmosphere
4: sulfuric acid / methanol / 8 h / Reflux; Inert atmosphere
5: trichlorophosphate / N,N-dimethyl-formamide / 55 - 100 °C / Inert atmosphere
6: hydroxylamine hydrochloride; dihydrogen peroxide; hydrogenchloride / acetonitrile / 5 h / 80 °C / Inert atmosphere
7: potassium hydroxide / ethanol; water / 1 h / Reflux; Inert atmosphere
With
hydrogenchloride; potassium cyanide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; phosphorus tribromide; potassium hydroxide; trichlorophosphate;
In
1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.tet.2014.01.009
