N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

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Chemical Name:N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea
CAS No.:540781-58-6
Molecular Formula:C₂₇H₃₀F₄N₄O₂
Molecular Weight:518.554
Hs Code.:

Synonyms:N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

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Chemical Property of N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

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Technology Process of N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

There total 5 articles about N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 540787-50-6
1-[2-(1-pyrrolidinyl)ethylamino]-4-(3-cyanophenyl)-4-hydroxycyclohexane

: 1-fluoro-4-isocyanato-2-(trifluoromethyl)benzene

: 540781-58-6
N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2005.12.046

Reference yield:

: 540787-52-8
4-(3-cyanophenyl)-4-hydroxycyclohexan-1-one ethylene ketal

: 540781-58-6
N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / acetone; toluenesulfonic acid monohydrate / 1 h / Heating

2: 45 percent / NaCNBH₃ / CH₂Cl₂ / 20 °C

3: 80 percent / i-Pr₂NEt / CH₂Cl₂

With sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; acetone; In dichloromethane;
DOI:10.1016/j.bmc.2005.12.046

Reference yield:

: 887950-87-0
4-(3-cyanophenyl)-4-hydroxycyclohexan-1-one

: 540781-58-6
N'-(4-fluoro-3-trifluoromethyl-phenyl)-N-[4-(3-cyanophenyl)-4-hydroxycyclohexyl]-N-[2-(1-pyrrolidinyl)ethyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / NaCNBH₃ / CH₂Cl₂ / 20 °C

2: 80 percent / i-Pr₂NEt / CH₂Cl₂

With sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2005.12.046