L-Phe-[CH₂SO₂]-FHCl

Base Information

• Chemical Name: L-Phe-[CH₂SO₂]-FHCl
• CAS No.: 1300689-96-6
• Molecular Formula: C₉H₁₂FNO₂S*ClH
• Molecular Weight: 253.725
• Mol file: 1300689-96-6.mol

Synonyms:L-Phe-[CH₂SO₂]-FHCl

Chemical Property of L-Phe-[CH₂SO₂]-FHCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Phe-[CH₂SO₂]-FHCl

There total 9 articles about L-Phe-[CH₂SO₂]-FHCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-Phe-ψ[CH2SO2]-F (1169199-24-9) → L-Phe-[CH2SO2]-FHCl (1300689-96-6)

Guidance literature:

Cbz-Phe-ψ[CH2SO2]-F; With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

In water; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.bmc.2011.02.014

Reference yield:

N-((benzyloxy)carbonyl)-L-phenylalaninol (6372-14-1) → L-Phe-[CH2SO2]-FHCl (1300689-96-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: water; dihydrogen peroxide; acetic acid / 20 °C

4.1: 10% palladium on activated charcoal; sodium acetate / water / 20 °C

4.2: 20 °C

5.1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

5.2: Dowex 2X₈ chloride form / 0.08 h / 20 °C

With 10% palladium on activated charcoal; water; hydrogen bromide; dihydrogen peroxide; sodium acetate; caesium carbonate; acetic acid; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.02.014

Reference yield:

(S)-2-<(benzyloxycarbonyl)amino>-3-phenylpropyl ethanethioate (82001-62-5) → L-Phe-[CH2SO2]-FHCl (1300689-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; dihydrogen peroxide; acetic acid / 20 °C

2.1: 10% palladium on activated charcoal; sodium acetate / water / 20 °C

2.2: 20 °C

3.1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

3.2: Dowex 2X₈ chloride form / 0.08 h / 20 °C

With 10% palladium on activated charcoal; water; hydrogen bromide; dihydrogen peroxide; sodium acetate; acetic acid; In dichloromethane; water;

DOI:10.1016/j.bmc.2011.02.014

upstream raw materials:

Cbz-Phe-ψ[CH2SO2]-F

N-Cbz-L-Phe

N-((benzyloxy)carbonyl)-L-phenylalaninol

Z-Phe-O-COO-isoBu