(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
CAS No.:252016-92-5
Molecular Formula:C₁₈H₁₆ClF₃N₂O₄S
Molecular Weight:448.85
Hs Code.:

Synonyms:(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Chemical Property of (R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Technology Process of (R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 3 articles about (R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 20986-40-7
ethyl 5-bromo-3-pyridinecarboxylate

: 252019-49-1
(R)-N-(2-chloro-4-(triisopropylsilylsulphanyl)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 252016-92-5
(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: With caesium fluoride; copper(I) chloride; In 2,4-dichlorophenoxyacetic acid dimethylamine; ethyl acetate;

Reference yield:

: 242139-87-3
(R)-N-[2-chloro-4-iodophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 252016-92-5
(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / ethyl acetate; toluene; mineral oil

2: caesium fluoride / copper(I) chloride / 2,4-dichlorophenoxyacetic acid dimethylamine; ethyl acetate

With caesium fluoride; copper(I) chloride; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 2,4-dichlorophenoxyacetic acid dimethylamine; ethyl acetate; toluene; mineral oil;

Reference yield:

: 42016-93-3
2-chloro-4-iodoaniline

: 252016-92-5
(R)-N-{2-Chloro-4-([5-ethoxycarbonyl-pyridin-3-yl]sulphanyl)phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide

2: tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / ethyl acetate; toluene; mineral oil

3: caesium fluoride / copper(I) chloride / 2,4-dichlorophenoxyacetic acid dimethylamine; ethyl acetate

With caesium fluoride; copper(I) chloride; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; 2,4-dichlorophenoxyacetic acid dimethylamine; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;