(1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine

Base Information

• Chemical Name: (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine
• CAS No.: 211116-64-2
• Molecular Formula: C₁₅H₁₈INO₂
• Molecular Weight: 371.218
• Mol file: 211116-64-2.mol

Synonyms:(1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine

Chemical Property of (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine

There total 1 articles about (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodophenylamine (615-43-0) + 8-Chloromethyl-1,4-dioxa-spiro[4.5]dec-7-ene → (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine (211116-64-2)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C;

DOI:10.1021/ja980786p

Reference yield: 93.0%

methyl chloroformate (79-22-1) + (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-amine (211116-64-2) → (1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-carbamic acid methyl ester (142613-81-8)

Guidance literature:

With potassium carbonate;

DOI:10.1021/ja980786p

upstream raw materials:

2-iodophenylamine

Downstream raw materials:

(1,4-Dioxa-spiro[4.5]dec-7-en-8-ylmethyl)-(2-iodo-phenyl)-carbamic acid methyl ester