N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

Base Information

Chemical Name:N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester
CAS No.:256477-34-6
Molecular Formula:C₂₂H₂₂Cl₂N₂O₄S
Molecular Weight:481.4
Hs Code.:

Synonyms:N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

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Chemical Property of N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

Chemical Property:

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Technology Process of N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

There total 6 articles about N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223671-80-5
1,4-dichloro-7-isoquinolinesulphonyl chloride

hexanes-EtOAc: hexanes-EtOAc

: 7662-76-2
tert-butyl 2-(benzylamino)acetate

: 256477-34-6
N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

Guidance literature:: In dichloromethane; triethylamine;

Reference yield:

: 223671-80-5
1,4-dichloro-7-isoquinolinesulphonyl chloride

: N-benzylglycine tert-butyl ester hydrochloride

: 256477-34-6
N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1021/jm061066t

Reference yield:

: 491-30-5
1-isoquinolone

: 256477-34-6
N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 11.3 g / N-chlorosuccinimide / acetonitrile / 1.5 h / Heating

2: 18.75 g / ClSO₃H / 84 h / 100 °C

3: 20 g / POCl₃ / acetonitrile / 15 h / Heating

4: 290 mg / NEt₃ / CH₂Cl₂ / 72 h / 20 °C

With chlorosulfonic acid; N-chloro-succinimide; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;
DOI:10.1021/jm061066t