3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

Base Information

Chemical Name:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide
CAS No.:1351087-48-3
Molecular Formula:C₁₆H₂₀BrN₇O₃S
Molecular Weight:470.35
Hs Code.:

Synonyms:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

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Chemical Property of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

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Technology Process of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

There total 5 articles about 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1184378-69-5
3-amino-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

: 90914-41-3
3-bromo-4-chloropyrazolo<3,4-d>pyrimidine

: 1351087-48-3
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

Guidance literature:: With silver trifluoromethanesulfonate; In 1,4-dioxane; at 80 ℃; Sealed tube;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351087-48-3
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / -35 °C

3: silver trifluoromethanesulfonate / 18 h / 110 °C / Sealed tube; Microwave irradiation

4: hydrogen / palladium on activated charcoal / ethanol / 1 h / 20 °C / 1810.07 Torr

5: silver trifluoromethanesulfonate / 1,4-dioxane / 80 °C / Sealed tube

With chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351087-48-3
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[ethyl(2-hydroxyethyl)amino]-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2: silver trifluoromethanesulfonate / 18 h / 110 °C / Sealed tube; Microwave irradiation

3: hydrogen / palladium on activated charcoal / ethanol / 1 h / 20 °C / 1810.07 Torr

4: silver trifluoromethanesulfonate / 1,4-dioxane / 80 °C / Sealed tube

With hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol;