methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

Base Information

Chemical Name:methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate
CAS No.:1262133-54-9
Molecular Formula:C₁₈H₁₇ClN₄O₃
Molecular Weight:372.811
Hs Code.:

Synonyms:methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

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Chemical Property of methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

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Technology Process of methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

There total 10 articles about methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 1262133-53-8
7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1262133-54-9
methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 15 - 30 ℃; for 2.5h; Solvent; Large scale;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1262133-54-9
methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: bis(acetylacetonate)nickel(II) / 1,4-dioxane / 16 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 72 h / 20 °C

3.1: isopropyl alcohol / 0.5 h / Reflux

3.2: 0.5 h / 20 °C

4.1: trifluoroacetic anhydride / tetrahydrofuran / 22 h / Reflux

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; cyclopentyl methyl ether / 6 h / 50 °C

6.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

6.2: 1 h / Cooling with ice

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 2 h / 20 °C / Cooling with ice

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; trichlorophosphate; bis(acetylacetonate)nickel(II); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; cyclopentyl methyl ether; water; isopropyl alcohol;

Reference yield:

: 1262133-51-6
methyl (5,7-dichloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)carboxylate

: 1262133-54-9
methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; cyclopentyl methyl ether / 6 h / 50 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.2: 1 h / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 2 h / 20 °C / Cooling with ice

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; cyclopentyl methyl ether; water;