1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine

Base Information

• Chemical Name: 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine
• CAS No.: 1042665-07-5
• Molecular Formula: C₂₂H₂₅F₃N₄O₈
• Molecular Weight: 530.458

Synonyms:1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine

Chemical Property of 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine

Chemical Property:

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Technology Process of 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine

There total 1 articles about 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N⁴-benzoylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl}-N4-benzoylcytosine (1042664-96-9) → 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N4-benzoylcytosine (1042665-07-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2008.04.110

Reference yield: 86.0%

1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-β-D-ribofuranosyl}-N4-benzoylcytosine (1042665-07-5) + mono-4-methoxytrityl chloride (14470-28-1) → 1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}-N4-benzoylcytosine (1042665-15-5)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2008.04.110

upstream raw materials:

1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl}-N⁴-benzoylcytosine

Downstream raw materials:

1-{2-O-[(3-(2,2,2-trifluoroacetamido)propoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}-N⁴-benzoylcytosine

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