tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate
CAS No.:402508-97-8
Molecular Formula:C₃₃H₄₇ClN₄O₄SSi
Molecular Weight:659.365
Hs Code.:

tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Synonyms:tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

There total 6 articles about tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 213985-97-8
2-(4-aminophenyl)-N-thiazol-2-ylacetamide

: 174891-03-3
1,1-dimethylethyl ((2R)-2-(3-chlorophenyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)[(1R)-1-methyl-2-oxoethyl]carbamate

: 402508-97-8
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0101500

Reference yield:

: 2-(4-nitrophenyl)-N-thiazol-2-ylacetamide

: 402508-97-8
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂ / 10percent Pd/C / tetrahydrofuran; ethanol / 8 h / 20 °C / 760.05 Torr

2: 82 percent / NaBH(OAc)3; AcOH / CH₂Cl₂; dimethylformamide / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101500

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 402508-97-8
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl-((1R)-1-methyl-2-{4-[2-oxo-(1,3-thiazol-2-ylamino)ethyl]anilino}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 0.25 h / 90 - 95 °C

2: 96 percent / DIBAL / toluene / 1 h / -78 °C

3: 82 percent / NaBH(OAc)3; AcOH / CH₂Cl₂; dimethylformamide / 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0101500