(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

Base Information

Chemical Name:(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride
CAS No.:1283142-04-0
Molecular Formula:C₂₀H₂₃NO₄*ClH
Molecular Weight:377.868
Hs Code.:

Synonyms:(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

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Chemical Property of (S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

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Technology Process of (S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

There total 3 articles about (S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: (S)-ethyl 2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetate

: 1283142-04-0
(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 0.333333h;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1283142-04-0
(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: zinc / acetic acid / 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 130 °C

4: sodium hydroxide / water; 1,4-dioxane / 0.33 h / 20 °C

With sodium hydrogencarbonate; caesium carbonate; sodium hydroxide; zinc; In 1,4-dioxane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 2434-02-8,139456-82-9
ethyl tetrahydrofuran-2-acetate

: 1283142-04-0
(S)-2-(1-(4-(2-ethoxyphenoxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C

1.2: -78 - 20 °C

2.1: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 130 °C

3.1: sodium hydroxide / water; 1,4-dioxane / 0.33 h / 20 °C

With sodium hydrogencarbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.6b01559