imidapril

Base Information

• Chemical Name: imidapril
• CAS No.: 120294-10-2
• Molecular Formula: C₂₀H₂₇N₃O₆
• Molecular Weight: 405.451
• Mol file: 120294-10-2.mol

Synonyms:4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-

Chemical Property of imidapril

Chemical Property:

• Vapor Pressure: 3.71E-14mmHg at 25°C
• Boiling Point: 577°C at 760 mmHg
• Flash Point: 302.8°C
• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of imidapril

There total 4 articles about imidapril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

benzyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylate (89371-36-8) → imidapril (89371-37-9,120294-10-2)

Guidance literature:

palladium; In ethanol; hydrogen;

Reference yield: 68.1%

hydrogen chloride-dioxane + tert-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate (89371-38-0) → imidapril (89371-37-9,120294-10-2)

Guidance literature:

In ethyl acetate;

Reference yield:

tert-Butyl (4S)-3-<(2S)-2-amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate Hydrogenmaleate (117605-23-9) → imidapril (89371-37-9,120294-10-2)

Guidance literature:

With potassium carbonate; In water; Yield given;

DOI:10.1248/cpb.39.1374

upstream raw materials:

tert-Butyl (4S)-3-<(2S)-2-amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate Hydrogenmaleate

tert-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

benzyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylate

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