(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

Base Information

Chemical Name:(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide
CAS No.:113471-98-0
Molecular Formula:C₃₈H₄₃N₅O₄S₃
Molecular Weight:729.989
Hs Code.:

Synonyms:(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

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Technology Process of (R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

There total 1 articles about (R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91872-31-0
(S)-1-(2-naphthyl-sulfonyl)pyrrolidine-2-carbonyl chloride

: 103074-00-6
(N)-methyl-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

: 82625-38-5
2-(2-(4-phenylpiperazinyl)ethoxy)benzaldehyde

: 113471-98-0
(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

: 113471-99-1
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid methyl-((S)-2-{2-[2-(4-phenyl-piperazin-1-yl)-ethoxy]-phenyl}-thiazolidine-3-carbothioyl)-amide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.35.2412

Reference yield: 93.3%

: 113471-98-0
(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

: 91872-30-9
N-(2-naphthylsulfonyl)-(S)-proline

: 103076-24-0
(R)-N-methyl-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; methanol; for 15.5h; Ambient temperature;
DOI:10.1248/cpb.35.2412

Reference yield:

: 113471-98-0
(R)-N-methyl-N-(N-(2-naphthylsulfonyl)-L-prolyl)-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-thiocarboxamide

: 103073-96-7
(R)-N-methyl-2-(2-(2-(4-phenylpiperazino)ethoxy)phenyl)thiazolidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93.3 percent / NaOH/H₂O / methanol; tetrahydrofuran / 15.5 h / Ambient temperature

2: methyl trans-3-(4-methoxyphenyl)glycidate / ethanol / 14 h / Heating

With sodium hydroxide; methyl 3-(4-methoxyphenyl)glycidate; water; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.35.2412