{2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester

Base Information

• Chemical Name: {2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester
• CAS No.: 174626-80-3
• Molecular Formula: C₂₉H₃₁O₃PS₂
• Molecular Weight: 522.669

Synonyms:{2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester

Chemical Property of {2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of {2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester

There total 6 articles about {2-[2-Oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-(2-Ethoxycarbonylmethyl-[1,3]dithian-2-yl)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-butyric acid tert-butyl ester (174626-79-0) → {2-[2-Oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester (174626-80-3)

Guidance literature:

With acetic acid; at 90 ℃; for 24h;

DOI:10.1080/00397919608086738

Reference yield:

(tert-Butoxycarbonylmethylene)triphenylphosphorane (86302-43-4,35000-38-5) → {2-[2-Oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester (174626-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / benzene / 0.5 h / 8 °C

2: 73 percent / glacial AcOH / 24 h / 90 °C

With acetic acid; In benzene;

DOI:10.1080/00397919608086738

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → {2-[2-Oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-[1,3]dithian-2-yl}-acetic acid ethyl ester (174626-80-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / BF₃*Et₂O / CH₂Cl₂ / 48 h / Heating

2: 95 percent / aq. NaOH / ethanol / 0.5 h / Heating

3: COCl₂ / CH₂Cl₂

4: 77 percent / benzene / 0.5 h / 8 °C

5: 73 percent / glacial AcOH / 24 h / 90 °C

With sodium hydroxide; boron trifluoride diethyl etherate; acetic acid; In ethanol; dichloromethane; benzene;

DOI:10.1080/00397919608086738

upstream raw materials:

4-(2-Ethoxycarbonylmethyl-[1,3]dithian-2-yl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid tert-butyl ester

(tert-Butoxycarbonylmethylene)triphenylphosphorane

diethyl 1,3-acetonedicarboxylate

3-(1,3-dithian-2-yl)pentanedioic acid monoethylester

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