6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline

Base Information

Chemical Name:6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline
CAS No.:120546-67-0
Molecular Formula:C₁₀H₁₀N₂S
Molecular Weight:190.269
Hs Code.:
ChEMBL ID:CHEMBL41624
DSSTox Substance ID:DTXSID60562699
Wikidata:Q82446956
Mol file:120546-67-0.mol

Synonyms:120546-67-0;6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline;6,7,8,9-tetrahydro-[1,3]thiazolo[4,5-h]isoquinoline;CHEMBL41624;6,7,8,9-Tetrahydro[1,3]thiazolo[4,5-h]isoquinoline;DTXSID60562699

Suppliers and Price of 6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline
2.5mg
$ 165.00

Total 5 raw suppliers

Chemical Property of 6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline

Chemical Property:

PSA：53.16000
LogP:2.27080
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:190.05646950
Heavy Atom Count:13
Complexity:197

Purity/Quality:

98%min ^*data from raw suppliers

6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=C1C=CC3=C2SC=N3
Uses Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI) is a series of 7,8-fused heterocyclic tetrahydroisoquinolines were prepd. and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT).

Technology Process of 6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline

There total 2 articles about 6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 120546-66-9
2-Chloro-1,2,3,4-tetrahydrothiazolo<4,5-h>isoquinoline

: 120546-67-0
1,2,3,4-Tetrahydrothiazolo[4,5-h]isoquinoline

Guidance literature:: With phosphorus; hydrogen iodide; acetic acid; for 3h; Heating;
DOI:10.1021/jm00127a027

Reference yield:

: 35317-81-8
2-chloro-thiazolo[4,5-h]isoquinoline

: 120546-67-0
1,2,3,4-Tetrahydrothiazolo[4,5-h]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaBH₃CN, HCl-MeOH / methanol

2: 42 percent / red phosphorous, 47percent HI, HOAc / 3 h / Heating

With hydrogenchloride; phosphorus; hydrogen iodide; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/jm00127a027