Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI)

Base Information

• Chemical Name: Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI)
• CAS No.: 120546-67-0
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.269
• Mol file: 120546-67-0.mol

Synonyms:Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI)

Chemical Property of Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI)

Chemical Property:

• PSA: 53.16000
• LogP: 2.27080

Purity/Quality:

98%min ^*data from raw suppliers

6,7,8,9-Tetrahydrothiazolo[4,5-h]isoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI) is a series of 7,8-fused heterocyclic tetrahydroisoquinolines were prepd. and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT).

Technology Process of Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI)

There total 2 articles about Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-Chloro-1,2,3,4-tetrahydrothiazolo<4,5-h>isoquinoline (120546-66-9) → 1,2,3,4-Tetrahydrothiazolo[4,5-h]isoquinoline (120546-67-0)

Guidance literature:

With phosphorus; hydrogen iodide; acetic acid; for 3h; Heating;

DOI:10.1021/jm00127a027

Reference yield:

2-chloro-thiazolo[4,5-h]isoquinoline (35317-81-8) → 1,2,3,4-Tetrahydrothiazolo[4,5-h]isoquinoline (120546-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaBH₃CN, HCl-MeOH / methanol

2: 42 percent / red phosphorous, 47percent HI, HOAc / 3 h / Heating

With hydrogenchloride; phosphorus; hydrogen iodide; sodium cyanoborohydride; acetic acid; In methanol;

DOI:10.1021/jm00127a027

upstream raw materials:

2-Chloro-1,2,3,4-tetrahydrothiazolo<4,5-h>isoquinoline

2-chloro-thiazolo[4,5-h]isoquinoline

Refernces