(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

Base Information

Chemical Name:(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate
CAS No.:1218922-57-6
Molecular Formula:C₂₇H₃₁BrN₂O₈S
Molecular Weight:623.522
Hs Code.:

Synonyms:(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

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Chemical Property of (R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

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Technology Process of (R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

There total 1 articles about (R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1061743-26-7
(S)-tert-butyl 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutanoate

: 279246-01-4
tert-butyl ((4-bromophenyl)-sulfonyl)carbamate

: 1218922-57-6
(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm901868z

Reference yield: 98.0%

: 1218922-57-6
(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

: 1218922-58-7
(R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h;
DOI:10.1021/jm901868z

Reference yield: 71.0%

: 1218922-57-6
(R)-tert-butyl 2-(4-bromo-N-(tert-butoxycarbonyl)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1218922-59-8
(R)-tert-butyl 2-(N-(tert-butoxycarbonyl)-2'-(trifluoromethyl)biphenyl-4-ylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)butanoate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 85 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/jm901868z