threo-Pentaric acid, 3-deoxy-, 1,4-lactone (9CI)

Base Information

• Chemical Name: threo-Pentaric acid, 3-deoxy-, 1,4-lactone (9CI)
• CAS No.: 120742-25-8
• Molecular Formula: C₅H₆O₅
• Molecular Weight: 146.1
• Mol file: 120742-25-8.mol

Synonyms:DL-threo-Pentaricacid, 3-deoxy-, 1,4-lactone

Chemical Property of threo-Pentaric acid, 3-deoxy-, 1,4-lactone (9CI)

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-Pentaric acid, 3-deoxy-, 1,4-lactone (9CI)

There total 3 articles about threo-Pentaric acid, 3-deoxy-, 1,4-lactone (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

d,l-α,α'-dihydroxyglutaric acid (33012-67-8,33012-68-9,54516-06-2,82864-77-5,120924-87-0) → cis-2-hydroxy-4-carbonyl-γ-butyrolactone (91113-89-2,120742-25-8,123406-37-1)

Guidance literature:

In neat (no solvent); at 135 - 145 ℃; under 10 - 15 Torr;

DOI:10.1007/BF00953295

Reference yield: 24.2%

meso-α,α'-dibromoglutaric acid (3425-64-7) → meso-α,α'-dihydroxyglutaric acid (33012-67-8) + trans-2-hydroxy-4-carboxy-γ-butyrolactone (91113-89-2,120742-25-8,123406-37-1)

Guidance literature:

With sodium carbonate;

DOI:10.1007/BF00953295

Reference yield:

d,l-α,α'-dibromoglutaric acid (3425-64-7,3425-66-9,3479-80-9) → cis-2-hydroxy-4-carbonyl-γ-butyrolactone (91113-89-2,120742-25-8,123406-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / 2 N aq. sodium carbonate / 1.5 h / Heating

2: 93 percent / neat (no solvent) / 135 - 145 °C / 10 - 15 Torr

With sodium carbonate; In neat (no solvent);

DOI:10.1007/BF00953295

upstream raw materials:

d,l-α,α'-dihydroxyglutaric acid

d,l-α,α'-dibromoglutaric acid

meso-α,α'-dibromoglutaric acid

Downstream raw materials:

2-buten-4-olide

trans-2-hydroxy-4-methoxycarbonyl-γ-butyrolactone

dimethyl meso-α,α'-dihydroxyglutarate

cis-2-hydroxy-4-methoxycarbonyl-γ-butyrolactone

Refernces